Sweeney gained wider recognition for her roles in the HBO drama series Euphoria (2019–present) and the first season of the anthology series The White Lotus (2021), which earned her nominations for two Primetime Emmy Awards.[2][3] In 2023, she portrayed Reality Winner in the drama film Reality and led the commercially successful romantic comedy Anyone but You. In 2024, she starred in the superhero film Madame Web, and produced and starred in the horror film Immaculate.
Over the last 50 years, survival rates for childhood cancer have risen from 10 percent chance of survival to nearly 80 percent. MPC has partnered with Blood Cancer UK annually since 2017, providing funding for research in the fight against blood cancer, including fully funding a clinical trial.